Selection of a self-cleaving ribozyme activated in a chemically and thermally denaturing environment

Lingfei Ma, Zhicheng Huang, Juewen Liu


Abstract
A self-cleaving ribozyme was obtained from <italic>in vitro</italic> selection, displaying site-specific cleavage activity under various denaturing conditions, such as high temperatures, 20 M formamide, and low salt concentrations.
Cite:
Lingfei Ma, Zhicheng Huang, and Juewen Liu. 2021. Selection of a self-cleaving ribozyme activated in a chemically and thermally denaturing environment. Chemical Communications, Volume 57, Issue 62, 57(62):7641–7644.
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