Emergence and Spread of the SARS-CoV-2 Omicron Variant in Alberta Communities Revealed by Wastewater Monitoring
Casey R. J. Hubert, Nicole Acosta, Barbara Waddell, Maria E. Hasing, Yuanyuan Qiu, Meghan Fuzzen, Nathanael B.J. Harper, María A. Bautista, Tiejun Gao, Chloe Papparis, Jenn Van Doorn, Kristine Du, Kevin Xiang, Leslie Chan, Laura Vivas, Puja Pradhan, Janine McCalder, Kashtin Low, Whitney England, Darina Kuzma, John Conly, M. Cathryn Ryan, Gopal Achari, Jia Hu, Jason Cabaj, Chris Sikora, Lawrence W. Svenson, Nathan Zelyas, Mark R. Servos, Jon Meddings, Steve E. Hrudey, Kevin J. Frankowski, Michael D. Parkins, Xiaoli Pang, Bonita E. Lee
Abstract
Abstract Wastewater monitoring of SARS-CoV-2 allows for early detection and monitoring of COVID-19 burden in communities and can track specific variants of concern. Targeted assays enabled relative proportions of SARS-CoV-2 Omicron and Delta variants to be determined across 30 municipalities covering >75% of the province of Alberta (pop. 4.5M) in Canada, from November 2021 to January 2022. Larger cities like Calgary and Edmonton exhibited a more rapid emergence of Omicron relative to smaller and more remote municipalities. Notable exceptions were Banff, a small international resort town, and Fort McMurray, a more remote northern city with a large fly-in worker population. The integrated wastewater signal revealed that the Omicron variant represented close to 100% of SARS-CoV-2 burden prior to the observed increase in newly diagnosed clinical cases throughout Alberta, which peaked two weeks later. These findings demonstrate that wastewater monitoring offers early and reliable population-level results for establishing the extent and spread of emerging pathogens including SARS-CoV-2 variants.- Cite:
- Casey R. J. Hubert, Nicole Acosta, Barbara Waddell, Maria E. Hasing, Yuanyuan Qiu, Meghan Fuzzen, Nathanael B.J. Harper, María A. Bautista, Tiejun Gao, Chloe Papparis, Jenn Van Doorn, Kristine Du, Kevin Xiang, Leslie Chan, Laura Vivas, Puja Pradhan, Janine McCalder, Kashtin Low, Whitney England, et al.. 2022. Emergence and Spread of the SARS-CoV-2 Omicron Variant in Alberta Communities Revealed by Wastewater Monitoring.
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@article{Hubert-2022-Emergence,
title = "Emergence and Spread of the SARS-CoV-2 Omicron Variant in Alberta Communities Revealed by Wastewater Monitoring",
author = "Hubert, Casey R. J. and
Acosta, Nicole and
Waddell, Barbara and
Hasing, Maria E. and
Qiu, Yuanyuan and
Fuzzen, Meghan and
Harper, Nathanael B.J. and
Bautista, Mar{\'\i}a A. and
Gao, Tiejun and
Papparis, Chloe and
Doorn, Jenn Van and
Du, Kristine and
Xiang, Kevin and
Chan, Leslie and
Vivas, Laura and
Pradhan, Puja and
McCalder, Janine and
Low, Kashtin and
England, Whitney and
Kuzma, Darina and
Conly, John and
Ryan, M. Cathryn and
Achari, Gopal and
Hu, Jia and
Cabaj, Jason and
Sikora, Chris and
Svenson, Lawrence W. and
Zelyas, Nathan and
Servos, Mark R. and
Meddings, Jon and
Hrudey, Steve E. and
Frankowski, Kevin J. and
Parkins, Michael D. and
Pang, Xiaoli and
Lee, Bonita E.",
journal = "",
year = "2022",
publisher = "Research Square Platform LLC",
url = "https://gwf-uwaterloo.github.io/gwf-publications/G22-18003",
doi = "10.1101/2022.03.07.22272055",
abstract = "Abstract Wastewater monitoring of SARS-CoV-2 allows for early detection and monitoring of COVID-19 burden in communities and can track specific variants of concern. Targeted assays enabled relative proportions of SARS-CoV-2 Omicron and Delta variants to be determined across 30 municipalities covering {\textgreater}75{\%} of the province of Alberta (pop. 4.5M) in Canada, from November 2021 to January 2022. Larger cities like Calgary and Edmonton exhibited a more rapid emergence of Omicron relative to smaller and more remote municipalities. Notable exceptions were Banff, a small international resort town, and Fort McMurray, a more remote northern city with a large fly-in worker population. The integrated wastewater signal revealed that the Omicron variant represented close to 100{\%} of SARS-CoV-2 burden prior to the observed increase in newly diagnosed clinical cases throughout Alberta, which peaked two weeks later. These findings demonstrate that wastewater monitoring offers early and reliable population-level results for establishing the extent and spread of emerging pathogens including SARS-CoV-2 variants.",
}
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<abstract>Abstract Wastewater monitoring of SARS-CoV-2 allows for early detection and monitoring of COVID-19 burden in communities and can track specific variants of concern. Targeted assays enabled relative proportions of SARS-CoV-2 Omicron and Delta variants to be determined across 30 municipalities covering \textgreater75% of the province of Alberta (pop. 4.5M) in Canada, from November 2021 to January 2022. Larger cities like Calgary and Edmonton exhibited a more rapid emergence of Omicron relative to smaller and more remote municipalities. Notable exceptions were Banff, a small international resort town, and Fort McMurray, a more remote northern city with a large fly-in worker population. The integrated wastewater signal revealed that the Omicron variant represented close to 100% of SARS-CoV-2 burden prior to the observed increase in newly diagnosed clinical cases throughout Alberta, which peaked two weeks later. These findings demonstrate that wastewater monitoring offers early and reliable population-level results for establishing the extent and spread of emerging pathogens including SARS-CoV-2 variants.</abstract>
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%0 Journal Article %T Emergence and Spread of the SARS-CoV-2 Omicron Variant in Alberta Communities Revealed by Wastewater Monitoring %A Hubert, Casey R. J. %A Acosta, Nicole %A Waddell, Barbara %A Hasing, Maria E. %A Qiu, Yuanyuan %A Fuzzen, Meghan %A Harper, Nathanael B.J. %A Bautista, María A. %A Gao, Tiejun %A Papparis, Chloe %A Doorn, Jenn Van %A Du, Kristine %A Xiang, Kevin %A Chan, Leslie %A Vivas, Laura %A Pradhan, Puja %A McCalder, Janine %A Low, Kashtin %A England, Whitney %A Kuzma, Darina %A Conly, John %A Ryan, M. Cathryn %A Achari, Gopal %A Hu, Jia %A Cabaj, Jason %A Sikora, Chris %A Svenson, Lawrence W. %A Zelyas, Nathan %A Servos, Mark R. %A Meddings, Jon %A Hrudey, Steve E. %A Frankowski, Kevin J. %A Parkins, Michael D. %A Pang, Xiaoli %A Lee, Bonita E. %D 2022 %I Research Square Platform LLC %F Hubert-2022-Emergence %X Abstract Wastewater monitoring of SARS-CoV-2 allows for early detection and monitoring of COVID-19 burden in communities and can track specific variants of concern. Targeted assays enabled relative proportions of SARS-CoV-2 Omicron and Delta variants to be determined across 30 municipalities covering \textgreater75% of the province of Alberta (pop. 4.5M) in Canada, from November 2021 to January 2022. Larger cities like Calgary and Edmonton exhibited a more rapid emergence of Omicron relative to smaller and more remote municipalities. Notable exceptions were Banff, a small international resort town, and Fort McMurray, a more remote northern city with a large fly-in worker population. The integrated wastewater signal revealed that the Omicron variant represented close to 100% of SARS-CoV-2 burden prior to the observed increase in newly diagnosed clinical cases throughout Alberta, which peaked two weeks later. These findings demonstrate that wastewater monitoring offers early and reliable population-level results for establishing the extent and spread of emerging pathogens including SARS-CoV-2 variants. %R 10.1101/2022.03.07.22272055 %U https://gwf-uwaterloo.github.io/gwf-publications/G22-18003 %U https://doi.org/10.1101/2022.03.07.22272055
Markdown (Informal)
[Emergence and Spread of the SARS-CoV-2 Omicron Variant in Alberta Communities Revealed by Wastewater Monitoring](https://gwf-uwaterloo.github.io/gwf-publications/G22-18003) (Hubert et al., GWF 2022)
- Emergence and Spread of the SARS-CoV-2 Omicron Variant in Alberta Communities Revealed by Wastewater Monitoring (Hubert et al., GWF 2022)
ACL
- Casey R. J. Hubert, Nicole Acosta, Barbara Waddell, Maria E. Hasing, Yuanyuan Qiu, Meghan Fuzzen, Nathanael B.J. Harper, María A. Bautista, Tiejun Gao, Chloe Papparis, Jenn Van Doorn, Kristine Du, Kevin Xiang, Leslie Chan, Laura Vivas, Puja Pradhan, Janine McCalder, Kashtin Low, Whitney England, et al.. 2022. Emergence and Spread of the SARS-CoV-2 Omicron Variant in Alberta Communities Revealed by Wastewater Monitoring.